Yes, the rules will apply to a real estate-related transaction, unless one of the exceptions apply.
A real estate-related financial transaction means any transaction involving:
(1) The sale, lease, purchase, investment in or exchange of real property, including interests in property, or the financing thereof; or
(2) The refinancing of real property or interests in real property; or
(3) The use of real property or interests in property as security for a loan or investment, including mortgage-backed securities.
Here is a link to the exceptions: https://www.law.cornell.edu/cfr/text/12/323.3